Zootecnica International - World Poultry Journal

With funding from USDA's Cooperative State Research, Education, and Extension Service (CSREES) National Research Initiative (NRI), scientists in Arizona (USA) are developing a new vaccine for this poultry disease, which, in turn, may improve animal and human health.
The United States is the world leader in the poultry industry, with annual profits of $50 billion; however, food pathogens threaten the industry. Scientists are especially concerned about Avian Pathogenic Escherichia coli (APEC), which caused an estimated $80 million in losses in 2002.
APEC has the potential to be as harmful as E. coli O157:H7, the strain respon sible for human illness and death after consumption of contaminated meat. The genetic similarity between APEC and human E. coli has led scientists to suspect poultry as a source of Extra-intestinal Pathogenic E. coli (ExPEC), which is associated with urethral infections, sepsis, and meningitis.
Dr. Roy Curtiss and colleagues at Arizona State University began by identifying how E. coli evaded the host's immune system. The researchers used the E. coli bacterial genome to identify the specific genes responsible for triggering its harmful effects. The vaccine produced during this project may lead to additional protection for humans against another pathogen, Salmonella.
"We have to understand how bacteria cause disease so that we can know the best way to fight them," associate research scientist Melha Mellata said. "We came up with a project where we would protect chickens, not only from E. coli infection, but also Salmonella, and in doing so, improve human health."
Vaccine production for E. coli and Salmonella groups is complicated by the genetic diversity of each bacterium. The new vaccine under development in Curtiss' laboratory is designed to be effective against both E. coli and Salmonella. Curtiss has already developed three vaccines that are effective against multiple strains of Salmonella in livestock. By freeing animals from Salmonella, the vaccine may prevent it from travelling down the food chain to people. The vaccines, which were approved by the FDA for use in swine and poultry, are currently on the market.
CSREES funded this research project through the NRI Food Safety program. Through federal funding and leadership for research, education and extension programs, CSREES focuses on investing in science and solving critical issues impacting people's daily lives and the nation's future.